Current changes in cannabis regulatory policies, fueled by the debate over its medical use, spell out a political engagement allied with an epistemic work of producing knowledge about this plant and its properties in order to challenge prohibitionist regulation and (re-)normalize the relationship between humans and cannabis from a therapeutic perspective. This is a broad issue that encompasses different knowledge fields such as public health, security, international relations, political economy and involves moral issues as individual liberty, human agency and inequality. In this context, this open panel seeks to bring together researchers dedicated to the theme of regulating the uses of cannabis with the aim of promoting a reflexive debate on the implications of these recent developments for the STS field and for society. Papers analyzing the prohibitionist paradigm and its political, economic, legal and scientific implications and the emergence of new modes of regulation and research on the use, cultivation, commercialization, production of sociability and knowledge about the plant are welcome. The proposal converges with the theme of the conference around Good Relations, the modes of knowledge production that link scientific practices with practices of solidarity and care, of combating structures of inequality and oppression, of relations between humans and non-humans, in a highly politicized field of studies and focused on the research of a morally saturated plant and whose connections with processes of domination over minorities are established in the scientific literature.